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KMID : 1123920180320010043
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Korean Journal of Oriental Physiology and Pathology
2018 Volume.32 No. 1 p.43 ~ p.50
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Effect of Korean Red Ginseng on Hypertriglyceridemia in High Fat/high Cholesterol Diet Rat Model
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Kim Hye-Yoom
Jin Xian-Jun
Hong Mi-Hyeon
Ko Seon-Mi
Hwang Seung-Mi
Im Dong-Joong
Ahn You-Mee
Lee Ho-Sub
Kang Dae-Gill
Lee Yun-Jung
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Abstract
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Korean Red Ginseng (RG) are used as a traditional treatment for improve blood circulation. This experimental study was designed to investigate the inhibitory effects of Korean red ginseng on lipid metabolism in high fat/cholesterol diet (HFCD)-induced hypertriglyceridemia. Sprague Dawley rats were fed the HFCD diet with/without fluvastatin (Flu, positive control) 3 mg/kg/day, and RG 125 or 250 mg/kg/day, respectively. All groups received regular diet or HFCD diet, respectively, for 13 weeks. The last three groups treatment of Flu and RG 125, and RG 250 orally for a period of 9 weeks. Group 1, reular diet; group 2, HFCD diet; group 3, Flu + HFCD diet; group 4, RG 125 + HFCD diet; group 5, RG 250 + HFCD diet. As a result, treatment with low or high doses of RG markedly attenuated plasma levels of triglycerides and augmented plasma levels of high-density lipoprotein (HDL) in HFCD-fed rats. RG and Flu also led to an increase in lipoprotein lipase activity in the HFCD group. On the other hand, RG and Flu led to an decrease in fatty acid synthase and free fatty acid activity in the HFCD group. Treatment with RG suppressed increased expressions of PPAR-α and AMPK in HFCD rat liver or muscle. In addition, the RG attenuated triglyceridemia by inhibition of PPAR-γ and FABP protein expression levels and LXR and SREBP-1 gene expression in liver or muscle. The RG significantly prevented the development of the metabolic disturbances such as hypertriglyceridemia and hyperlipidemia. Taken together, the administration of RG improves hypertriglyceridemia through the alteration in suppression of triglyceride synthesis and accentuated of triglyceride decomposition. These results suggested that RG is useful in the prevention or treatment of hypertriglyceridemia.
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KEYWORD
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Korean Red Ginseng, Triglyceride, Hypertriglyceridemia, Triglyceride synthesis, Metabolism
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